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7.4.1.4 Insulin-like growth factor-1 (IGF-1) IGF-1 is a potent neurotrophic factor that is involved in the regulation of neuronal growth and survival

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107,108 In ME2-unexpressed gastric cancer cells, its isoenzyme ME1 is upregulated to replenish intracellular NADPH and promotes cell survival under glucose starvation and anoikis

A meta-analysis of the association between two cardiac risk factors

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Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)